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Meningeal involvement in bence jones multiple myeloma

✍ Scribed by Kenji Oda; Hiromi Egawa; Taneomi Okuhara; Akira Sakai; Hideo Hyohdou; Hideo Tanaka; Atsushi Kuramoto

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 366 KB
Volume: 67
Category: Article
ISSN: 0008-543X
DOI: 10.1002/1097-0142(19910401)67:7<1900::aid-cncr2820670714>3.0.co;2-a

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✦ Synopsis

A case of Bence Jones kappa multiple myeloma with meningeal involvement in a 64-year-old woman is presented. Three years after the diagnosis of multiple myeloma, gait disturbances developed followed by visual disorders and impaired consciousness. A lumbar puncture revealed numerous atypical plasma cells in the cerebrospinal fluid. Craniospinal irradiation and intrathecal injections of methotrexate, cytarabine, and prednisolone were effective for a short period. At autopsy, the leptomeninges were infiltrated diffusely with atypical plasma cells. A review of the literature showed that multiple myeloma with meningeal involvement is accompanied frequently by circulating atypical plasma cells or plasma cell leukemia. Meningeal involvement is a rare complication and shows poor prognosis in cases of multiple myeloma.

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