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Meningeal infiltration in recurrent nasopharyngeal carcinoma

✍ Scribed by Chong, Vincent Fh ;Fan, Yoke-Fun

Book ID
104470170
Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
124 KB
Volume
44
Category
Article
ISSN
0004-8461

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✦ Synopsis

SUMMARY

Permeative infiltration of the meninges appears to be a distinct form of recurrent nasopharyngeal carcinoma (NPC). The present report of eight patients with recurrent NPC illustrates meningeal infiltration following basal foramina extension. Seven of the eight patients (88%) showed jugular foramen involvement. Three patients had concomitant infiltration of the foramen magnum. There was one patient showing spread through the foramen lacerum. Only four (50%) of these patients had clinically detectable tumour in the nasopharynx, while the other half showed deep submucosal recurrence with endoscopically unremarkable findings. Permeative meningeal infiltration appears to be a distinct form of NPC recurrence. It is important to recognize this phenomenon so as to optimize the treatment options.

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Background. Any malignancy has the propensity to metastasize to skin. The frequency of skin metastases vary in different tumors and occur in about 0.7% to 10% 1-3 of all patients diagnosed with cancer. It is rare in nasopharyngeal carcinoma. Method. Three cases of relapsed nasopharyngeal carcinoma