Memory in helper T cells of minor histocompatibility antigens, revealed in vivo by alloimmunizations in combination with Thy-1 antigen

✍ Scribed by Elizabeth Lightstone; Jacqueline Marvel; Avrion Mitchison

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 773 KB
• Volume: 22
• Category: Article
• ISSN: 0014-2980
• DOI: 10.1002/eji.1830220118

✦ Synopsis

Memory in helper Tcells of minor histocompatibility antigens, revealed in vivo by alloimmunizations in combination with Thy-1 antigen

A cooperative antibody response in which T helper (Th) cells recognize minor histocompatibility antigens (mha) and B cells recognize Thy-1 antigen, is used to explore memory in the Tcell compartment. In contrast to B cell memory, T h memory reaches a plateau rapidly, although T h memory of Thy-1 itself (or an associated antigen) behaves exceptionally in this respect. The plateau then extends over several weeks at least. Single mha, among them H-Y, generate detectable memory. Incompatible H-2 antigens, including class I antigens on their own, inhibit this response through what appears to be a mechanism of intracellular antigenic competition. Antigen presentation in this system is by host cells, as judged by lack of donor-specific restriction. Memory resides in both the CD45RAf and CD45RA-compartments, although the majority of memory T h cells have the latter phenotype.