Memory impairments induced by peripherally administered cholecystokinin a-type receptor antagonists in rats

✍ Scribed by Shinji Itoh; Akira Takashima; Yumino Maeda

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 571 KB
• Volume: 26
• Category: Article
• ISSN: 0272-4391
• DOI: 10.1002/ddr.430260108

✦ Synopsis

Itoh, S., A. Takashima, and Y. Maeda: Memory impairments induced by peripherally administered cholecystokinin A-type receptor antagonists in rats. Drug Dev. Res. 26:89- 99, 1992. lntraperitoneal injection of cholecystokinin (CCK) A-type receptor antagonists, L-364,718 and CR 1409, caused dose-dependent memory impairments in passive and active avoidance responses and in Morris water pool test in rats. These antagonist effects were significant at a dose of 1 mg/kg, while with proglumide, 50-100 mg/kg were required to produce a similar memory deficit. The results suggest that loss of biologically active CCK octapeptide (CCKS), not only in the brain but also in the peripheral tissues, causes memory impairments in rats. o 1992 Wiley-Liss, Inc.