Memory facilitation with atropine: a paradoxical effect

✍ Scribed by C. Ghelardini; N. Galeotti; F. Gualtieri; C. Bellucci; A. Bartolini

• Book ID: 101288487
• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 98 KB
• Volume: 12
• Category: Article
• ISSN: 0951-418X
• DOI: 10.1002/(sici)1099-1573(1998)12:1+<s7::aid-ptr233>3.0.co;2-r

✦ Synopsis

The potential antiamnesic properties of atropine were investigated in the mouse passive avoidance test. Amnesia was induced by scopolamine (2 mg/kg i.p.) and by exposure to a hypoxic environment (5% O 2 in water-saturated nitrogen) for 8 min. Atropine (1-10 mg/kg s.c.) completely prevented disrupted acquisition without improving learning in mice with memory deficiency. At the same doses atropine did not produce any behavioural side effects in mice.