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Membrane-type-1 matrix metalloproteinase, matrix metalloproteinase 2, and tissue inhibitor of matrix proteinase 2 in prostate cancer: identification of patients with poor prognosis by immunohistochemistry

✍ Scribed by Dominique Trudel; Yves Fradet; François Meyer; François Harel; Bernard Têtu

Book ID
116534454
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
612 KB
Volume
39
Category
Article
ISSN
1532-8392

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Matrix metalloproteinase 2 (MMP-2) plays a crucial role in invasion and metastasis of malignant tumors. Membrane type 1-MMP (MT1-MMP) was originally identified as an activator of MMP-2. Tissue inhibitor of MMP-2 (TIMP-2) was identified as an inhibitor of MMP-2 and MT1-MMP. However, TIMP-2 was report