## Synopsis Substance P (Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2), a neuromodulator involved in the transmission of pain information, exerts its biological effects by binding to membrane-embedded protein receptors. The influence of membrane lipids on neuropeptide conformation may be critic
Membrane Structure of Substance P. I. Prediction of Preferred Conformation, Orientation, and Accumulation of Substance P on Lipid Membranes
β Scribed by Robert Schwyzer; Daniel Erne; Krzysztof Rolka
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- German
- Weight
- 600 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0018-019X
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## Honggerberg (5.VI11.86
Comparative CD studies with substance P (l), [Leuy]substance P ([Leu9]-l), and their shorter peptide segments supported the membrane structures predicted for substance P and (Leu']substance P. They indicated that the C-terminal segments (from residue 3 or 4 onward) can adopt a-helical conformations
Mixtures of egg yolk lecithin and phosphonic acid diethyl or dibutyl esters of the general type RP(O) (OR'): with R = hexane or dodecane were studied at low water concentration using 3~p. and :H-NMR. (1) The esters cause a phase transition Lo--H H at room temperature. This cannot be observed in pure