Membrane specificity of non-monotonic trends in cation-mediated injury to rapidly frozen phospholipid vesicles
✍ Scribed by Charles A. Brearley; Norman A. Hodges; Cedric J. Olliff
- Book ID
- 103041619
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 375 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0009-3084
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✦ Synopsis
Phospholipid vesicles like erythrocyte ghosts [1] have been shown to display trends in freeze-thaw injury with Group I ions which are non-monotonic in nature. That is to say, the relative extent of injury with such ions, measured as calcein release, does not follow a lyotropic series related solely to the hydrated ionic radii of these ions. By incorporation of cholesterol into the vesicles the non-monotonic nature of these trends has been shown to be highly membrane specific. Thus the non-monotonic trends in cation mediated freeze-thaw injury are shown to be independent of bulk solution properties.