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Membrane proteins and Aβ peptide toxicity

✍ Scribed by Manzoni, Claudia; Colombo, Laura; Messa, Massimo; Cagnotto, Alfredo; Balducci, Claudia; Forloni, Gianluigi; Salmona, Mario


Book ID
123124532
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
60 KB
Volume
5
Category
Article
ISSN
1552-5260

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## Abstract Amyloid β peptide (Aβ) is implicated in the pathogenesis of Alzheimer's disease (AD). The peptide is toxic to neurons, possibly by causing initial synaptic dysfunction and neuronal membrane dystrophy, promoted by increased cellular Ca^2+^. Calpain (Ca^2+^‐dependent protease) and caspase