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Membrane protein turnover by the m-AAA protease in mitochondria depends on the transmembrane domains of its subunits

✍ Scribed by Korbel, Daniel; Wurth, Stephanie; Käser, Michael; Langer, Thomas


Book ID
110032538
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
182 KB
Volume
5
Category
Article
ISSN
1469-221X

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Both the neuronal IIA as well as the cardiac SkM2 isoform of the pore forming alpha-subunit of voltage dependent sodium channels are modulated by Protein Kinase A. While alphaIIA becomes attenuated upon PKA stimulation, alphaSkM2 becomes upregulated. PKC dependent phosphorylation of a serine, locate