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Membrane potential-regulated Ca2+ signalling in development and maturation of mammalian cerebellar granule cells

✍ Scribed by Shigetada Nakanishi; Makoto Okazawa


Book ID
110114056
Publisher
Cambridge University Press
Year
2006
Tongue
English
Weight
394 KB
Volume
575
Category
Article
ISSN
0022-3751

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Potentiation of the osmosensitive taurin
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## Abstract Hyposmolarity (βˆ’30%) in cultured cerebellar astrocytes raised cytosolic Ca^2+^ concentration ([Ca^2+^]~i~) from 160 to 400 nM and activated the osmosensitive taurine release (OTR) pathway. Although OTR is essentially [Ca^2+^]~i~‐independent, further increase in [Ca^2+^]~i~ by ionomycin