✦ LIBER ✦

Membrane organization in immunoglobulin E receptor signaling

✍ Scribed by Erin D Sheets; David Holowka; Barbara Baird

Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 98 KB
Volume: 3
Category: Article
ISSN: 1367-5931
DOI: 10.1016/s1367-5931(99)80017-9

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✦ Synopsis

The structure and dynamics of the plasma membrane are proposed to be critical for the initial steps of signal transduction by the high-affinity immunoglobulin E receptor. Recent experimental advances indicate that interactions between the high-affinity immunoglobulin E receptor and the tyrosine kinase Lyn with cholesterol- and sphingolipid-rich regions within the plasma membrane are important for receptor function. This accumulating evidence points to spatio-temporal control of immunoglobulin E receptor signaling by the organization of the plasma membrane; an attractive hypothesis is that ligand-dependent receptor aggregation causes the segregation of Lyn-containing ordered regions of the plasma membrane from disordered regions.

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