✦ LIBER ✦

Membrane-initiated effects of progesterone on calcium dependent signaling and activation of VEGF gene expression in retinal glial cells

✍ Scribed by Magdalena Swiatek-De Lange; Andreas Stampfl; Stefanie M. Hauck; Hans Zischka; Christian J. Gloeckner; Cornelia A. Deeg; Marius Ueffing

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 678 KB
Volume: 55
Category: Article
ISSN: 0894-1491
DOI: 10.1002/glia.20523

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Neurosteroids, such as progesterone, influence central nervous system development and function by regulating a broad spectrum of physiological processes. Here, we investigated membrane‐initiated actions of progesterone in the retina and identified the membrane‐associated progesterone receptor component 1 (PGRMC1). We found PGRMC1 expressed mainly in retinal Muller glia (RMG) and retinal pigment epithelium, and localized uniquely to microsomal and plasma membrane fractions. In RMG, membrane‐impermeable progesterone conjugate induced calcium influx and subsequent phosphatidylinositol 3‐kinase‐mediated phosphorylation of PKC and ERK‐1/2. Induction by progesterone also led to PKC‐dependent activation of VEGF gene expression and protein synthesis, suggesting a contribution of membrane‐initiated hormone effects to VEGF induced neovascularization within retina. © 2007 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Effects of pharmacologic antagonists of

Effects of pharmacologic antagonists of epidermal growth factor receptor, PI3K and MEK signal kinases on NF-κB and AP-1 activation and IL-8 and VEGF expression in human head and neck squamous cell carcinoma lines

✍ Caren C. Bancroft; Zhong Chen; Jason Yeh; John B. Sunwoo; Ning T. Yeh; Sadhana J 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 296 KB 👁 2 views

## Abstract We previously reported that expression of angiogenesis factors interleukin‐8 (IL‐8) and vascular endothelial growth factor (VEGF) is promoted by coactivation of transcription factors nuclear factor‐kappaB (NF‐κB) and activator protein‐1 (AP‐1) by interleukin‐1α in human head and neck sq