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Membrane Environment Imposes Unique Selection Pressures on Transmembrane Domains of G Protein-Coupled Receptors

✍ Scribed by Stephanie J. Spielman, Claus O. Wilke


Book ID
120762974
Publisher
Springer
Year
2013
Tongue
English
Weight
698 KB
Volume
76
Category
Article
ISSN
0022-2844

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## Abstract Transmembrane domains (TMDs) of G‐protein coupled receptors (GPCRs) have very low water solubility and often aggregate during purification and biophysical investigations. To circumvent this problem many laboratories add oligolysines to the __N__‐ and __C__‐termini of peptides that corre