The M current, IM, a voltage-dependent noninactivating K current, was recorded in NG108-15 neuroblastoma x glioma hybrid cells, using the whole-cell mode of the patch-clamp technique. We studied inhibition of the M current by bradykinin, phorbol dibutyrate (PDBu), an activator of protein kinase C (P
Membrane current responses of NG108-15 mouse neuroblastoma-rat glioma hybrid cells to bradykinin
β Scribed by Higashida, Haruhiro; Brown, D.A.
- Book ID
- 123227535
- Publisher
- Elsevier Science
- Year
- 1988
- Weight
- 80 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0921-8696
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Confocal fluorescence microscopy was used to study the bradykinin-induced calcium signals in the neuroblastoma x glioma cell line NG 108-15. We found that bradykinin induced a rise in free calcium, not only in the cytoplasm but also in the nucleus. The nuclear and cytosolic calcium concentrations we
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