Protectin (CD59) inhibits homologous complement-mediated cytolysis by preventing formation of the membrane attack complex at the point of insertion and polymerization of C9 into cell membranes. The present study investigated the expression and function of CD59 on human prostatic tumor cells in situ
Membrane attack complex of complement and 20 kDa homologous restriction factor (CD59) in myocardial infarction
โ Scribed by Toyohiro Tada; Hidechika Okada; Noriko Okada; Hisashi Tateyama; Harumi Suzuki; Youhei Takahashi; Tadaaki Eimoto
- Book ID
- 105067990
- Publisher
- Springer
- Year
- 1997
- Tongue
- English
- Weight
- 858 KB
- Volume
- 430
- Category
- Article
- ISSN
- 1432-2307
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The diagnosis of an acute myocardial infarction (MI) can be cumbersome for pathologists. Even with a positive nitroblue tetrazolium (NBT) reaction, haematoxylin and eosin (H&E) evaluation of the myocardial tissue can remain inconclusive. Early signs presumed diagnostic for myocardial infarction, suc
Human CD59 is a small membrane-bound glycoprotein that functions as an inhibitor of the membrane-attack complex (MAC) of the complement system by binding the complement proteins C8 and C9. The crystal structure of a soluble construct of CD59 has been determined to 2.1 A resolution. When compared wit