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Memantine reduces repetitive action potential firing in spinal cord nerve cell cultures

โœ Scribed by R. Netzer; H. Bigalke


Book ID
115883317
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
470 KB
Volume
186
Category
Article
ISSN
0014-2999

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Ralitoline and CI-953 are anticonvulsant compounds active in both maximal electroshock and kindling models of seizures with rodents. CI-953 (IC50 = 5 microM) and ralitoline (IC50 = 2 microM) both blocked sustained repetitive firing of sodium action potentials with effects on firing activity triggere