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Meloxicam ameliorates motor dysfunction and dopaminergic neurodegeneration by maintaining Akt-signaling in a mouse Parkinson's disease model

✍ Scribed by Yoshikazu Tasaki; Joe Yamamoto; Tomohiro Omura; Tomoki Sakaguchi; Norihisa Kimura; Ko-ichi Ohtaki; Takashi Ono; Manabu Suno; Masaru Asari; Tomoko Ohkubo; Toshihiro Noda; Toshio Awaya; Keiko Shimizu; Kazuo Matsubara

Book ID: 116774204
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 528 KB
Volume: 521
Category: Article
ISSN: 0304-3940
DOI: 10.1016/j.neulet.2012.05.045

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## Abstract Glial cell line‐derived neurotrophic factor (GDNF) has been shown to be neuroprotective in animal models of the dopamine deficiency in Parkinson's disease. To examine the role of the extracellular signal‐regulated kinases 1 and 2 (ERK1/2) in this process, we infused a single dose of GDN