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MELD accurately predicts mortality in patients with alcoholic hepatitis

✍ Scribed by Winston Dunn; Laith H. Jamil; Larry S. Brown; Russell H. Wiesner; W. Ray Kim; K. V. Narayanan Menon; Michael Malinchoc; Patrick S. Kamath; Vijay Shah

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
163 KB
Volume
41
Category
Article
ISSN
0270-9139

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✦ Synopsis

Assessing severity of disease in patients with alcoholic hepatitis (AH) is useful for predicting mortality, guiding treatment decisions, and stratifying patients for therapeutic trials. The traditional disease-specific prognostic model used for this purpose is the Maddrey discriminant function (DF). The model for end-stage liver disease (MELD) is a more recently developed scoring system that has been validated as an independent predictor of patient survival in candidates for liver transplantation. The aim of the present study was to examine the ability of MELD to predict mortality in patients with AH. A retrospective cohort study of 73 patients diagnosed with AH between 1995 and 2001 was performed at the Mayo Clinic in Rochester, Minnesota. MELD was the only independent predictor of mortality in patients with AH. MELD was comparable to DF in predicting 30-day mortality (c-statistic and 95%

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