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Melatonin protects against neurobehavioral and mitochondrial deficits in a chronic mouse model of Parkinson's disease

✍ Scribed by Gaurav Patki; Yuen-Sum Lau

Book ID
113842255
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
597 KB
Volume
99
Category
Article
ISSN
0091-3057

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## Abstract A typical feature of Parkinson's disease is the progressive loss of dopaminergic neurons in the substantia nigra, in which inhibition of mitochondrial complex I activity may play an important role. Rotenone or 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) inhibit the mitochondrial