𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Melatonin prevents brain oxidative stress induced by obstructive jaundice in rats

✍ Scribed by Adolfo Cruz; Isaac Túnez; Rubén Martínez; Juan Rafael Muñoz-Castañeda; Luz María Ramírez; Marta Recio; Luís Ochoa; Alvaro Arjona; Pedro Montilla; Jordi Muntané; Francisco J. Padillo

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
128 KB
Volume
85
Category
Article
ISSN
0360-4012

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The aim of the study was to analyze the impact of melatonin on brain oxidative stress in experimental biliary obstruction. Cholestasis was done by a double ligature and section of the extrahepatic biliary duct. Melatonin was injected intraperitoneally (500 μg/kg/day). Malondialdehyde (MDA), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) contents were determined in the brain tissue. Biliary obstruction raised MDA and reduced GSH contents in the cortex, cerebellum, and hypothalamus areas. Moreover, the scavenger enzyme activity significantly dropped in all areas of the brain. Melatonin drastically reduced MDA concentration and enhanced GSH concentration, as well as all antioxidant enzyme activity in all brain areas obtained from the bile duct–ligated animals. In conclusion, the treatment with melatonin decreased lipid peroxidation and recovered the antioxidant status in the brain from cholestatic animals. © 2007 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Hesperidin, an antioxidant flavonoid, pr
Hesperidin, an antioxidant flavonoid, prevents acrylonitrile-induced oxidative stress in rat brain
✍ El-Sayed M. El-Sayed; Osama M. Abo-Salem; Mohamed F. Abd-Ellah; Gamil M. Abd-All 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 209 KB

## Abstract Acrylonitrile (ACN) is a volatile, toxic liquid used as a monomer in the manufacture of synthetic rubber, styrene plastics, acrylic fiber, and adhesives. ACN is a potent neurotoxin. A role for free radical mediated lipid peroxidation in the toxicity of ACN has been suggested. We examine

Melatonin protects against taurolithocho
Melatonin protects against taurolithocholic-induced oxidative stress in rat liver
✍ Lorena Fuentes-Broto; Francisco J. Miana-Mena; Eduardo Piedrafita; César Berzosa 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 215 KB 👁 1 views

## Abstract Cholestasis, encountered in a variety of clinical disorders, is characterized by intracellular accumulation of toxic bile acids in the liver. Furthermore, oxidative stress plays an important role in the pathogenesis of bile acids. Taurolithocholic acid (TLC) was revealed in previous stu

Melatonin reduces protein and lipid oxid
Melatonin reduces protein and lipid oxidative damage induced by homocysteine in rat brain homogenates
✍ Santiago Ortega-Gutiérrez; Lorena Fuentes-Broto; Joaquín J. García; Marta López- 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 149 KB 👁 1 views

## Abstract Numerous data indicate that hyperhomocysteinemia is a risk factor for cardio‐ and cerebrovascular diseases. At least in part, homocysteine (HCY) impairs cerebrovascular function because it generates large numbers of free radicals. Since melatonin is a well‐known antioxidant, which reduc

Oxidative stress-induced metabolic alter
Oxidative stress-induced metabolic alterations in rat brain astrocytes studied by multinuclear NMR spectroscopy
✍ Annette Brand; Dieter Leibfritz; Christiane Richter-Landsberg 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 341 KB 👁 2 views

Oxidative stress in cultured astrocytes exerted by 30-min treatment with 50-200 µM H 2 O 2 caused timeand concentration-dependent effects on cellular metabolism. These changes were accompanied by alterations in cellular morphology. Using 31 P nuclear magnetic resonance (NMR) spectroscopy, the data d

Stress-induced activation of nitric oxid
Stress-induced activation of nitric oxide-producing neurons in the rat brain
✍ Krukoff, Teresa L.; Khalili, Panteha 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 427 KB 👁 3 views

Nitric oxide (NO) is a gaseous neurotransmitter that may mediate a decrease in sympathetic output to the periphery. This implication predicts that NO-producing neurons in the brain are activated in animals experiencing increased levels of sympathetic activity. To test this prediction, we subjected t