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Melatonin enhances pro-inflammatory cytokine levels and protects against Chagas disease

✍ Scribed by Fabricia Helena Santello; Eduardo Osório Frare; Leony Cristina Caetano; Míriam Paula AlonsoToldo; José Clóvis Do Prado Jr


Book ID
111264555
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
198 KB
Volume
45
Category
Article
ISSN
0742-3098

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## Abstract Pro‐inflammatory cytokines (PIC) impair islet viability and function by activating inflammatory pathways that induce both necrosis and apoptosis. The aim of this study was to utilize an in vitro rat islet model to evaluate the efficacy of a clinically approved IL‐1 receptor antagonist (