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Melatonin counteracts inducible mitochondrial nitric oxide synthase-dependent mitochondrial dysfunction in skeletal muscle of septic mice

✍ Scribed by Germaine Escames; Luis C. López; Víctor Tapias; Pilar Utrilla; Russel J. Reiter; Ana B. Hitos; Josefa León; María I. Rodríguez; Darío Acuña-Castroviejo

Book ID
111264287
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
203 KB
Volume
40
Category
Article
ISSN
0742-3098

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## Abstract Because the neurotoxic effects of the antifungal drug amphotericin B (AMB) closely resemble those ascribed to the highly reactive gaseous free radical nitric oxide (NO), we investigated the effect of AMB on NO production in rodent astrocytes. AMB caused a dose‐dependent increase of NO g