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Melatonin antagonizes hypoxia-mediated glioblastoma cell migration and invasion via inhibition of HIF-1α

✍ Scribed by Zhang, Yanmin; Liu, Qian; Wang, Fuwu; Ling, Eng-Ang; Liu, Shangming; Wang, Liyan; Yang, Yang; Yao, Linli; Chen, Xueran; Wang, Fen; Shi, Wei; Gao, Ming; Hao, Aijun

Book ID
120315715
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
727 KB
Volume
55
Category
Article
ISSN
0742-3098

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## Abstract Focal adhesion kinase (FAK) and hypoxia‐inducible factor (HIF‐1α) are both up‐regulated in glioblastoma multiforme (GBMs), particularly in invasive zones. Because FAK may play an important role in the invasion of glioma cells into the surrounding brain, we sought an agent that causes do