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Melanosomal Damage in Normal Human Melanocytes Induced by UVB and Metal Uptake—A Basis for the Pro-oxidant State of Melanoma

✍ Scribed by Shirley Gidanian; Mallory Mentelle; Frank L. Meyskens Jr; Patrick J. Farmer

Book ID
111413197
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
762 KB
Volume
84
Category
Article
ISSN
0031-8655

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Melanosomal Damage in Normal Human Melan
Melanosomal Damage in Normal Human Melanocytes Induced by UVB and Metal Uptake—A Basis for the Pro-oxidant State of Melanoma
✍ Shirley Gidanian; Mallory Mentelle; Frank L. Meyskens Jr; Patrick J. Farmer 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 762 KB

## Abstract Melanins are ubiquitous catecholic pigments, formed in organelles called melanosomes within melanocytes, the function of which is to protect skin against harmful effects of UV radiation. Melanosomes within melanoma cells are characteristically abnormal, with fragmented melanin and disru