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Melanoma with signet-ring cells in a peritoneal effusion

✍ Scribed by Theodore H. Niemann; Patricia A. Thomas

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
344 KB
Volume
12
Category
Article
ISSN
8755-1039

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✦ Synopsis

Melanoma may occasionally give rise to a malignant effusion and when this occurs it can present a challenging differential diagnosis. We present such a patient who developed a peritoneal effusion. Cytologic examination of the peritoneal fluid revealed individual malignant cells with prominent cytoplasmic vacuoles raising the possibility of a signet-ring cell adenocarcinoma. Immunohistochemical studies were indicative of a malignant melanoma. In this case we believe that the cytoplasmic vacuoles may be a degenerative phenomenon and as such may represent another mechanism for the development of a signet-ring morphology in malignant

melanoma.

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