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Melanocyte-directed enzyme prodrug therapy (MDEPT): development of a targeted treatment for malignant melanoma

✍ Scribed by Allan M. Jordan; Tariq H. Khan; Helen M.I. Osborn; Andrew Photiou; Patrick A. Riley


Book ID
108480745
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
202 KB
Volume
7
Category
Article
ISSN
0968-0896

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Gene-directed enzyme prodrug therapy for
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## Abstract ## Background Gene‐directed enzyme prodrug therapy (GDEPT) based on the __E. coli__ enzyme purine nucleoside phosphorylase (PNP) represents a new approach for treating slow growing tumours like prostate cancer (PCa). Expressed enzyme converts a systemically administered prodrug, fludar