Melanocortin receptors: their functions and regulation by physiological agonists and antagonists
β Scribed by Z.A. Abdel-Malek
- Book ID
- 105740622
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 79 KB
- Volume
- 58
- Category
- Article
- ISSN
- 1420-682X
No coin nor oath required. For personal study only.
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The action of two genetic loci-agouti and the melanocortin receptor-1 (Mc1r)have opposing effects in the control of mammalian pigmentation and ultimately determine the color of the pigment produced. In a recent paper, Ollmann et al. confirmed that the agouti protein acts via the Mc1r. They show that
## Abstract The melanocortin receptors are involved in many physiological functions, including pigmentation, sexual function, feeding behavior, and energy homeostasis, making them potential targets for drugs to treat obesity, sexual dysfunction, etc. Understanding the conformational basis of the re