## Abstract Following the first synthesis of tritiated α‐melanocyte‐stimulating hormone (α‐MSH, α‐melanotropin) in 1974 by Medzihradszky __et al.__, several α‐MSH analogs were designed containing between 2 and 12 tritium atoms, the latter of which displayed a specific radioactivity of 12.21 GBq/μmo
Melanocortin-1 receptor-targeting with radiolabeled cyclic α-melanocyte-stimulating hormone analogs for melanoma imaging
✍ Scribed by Paula D. Raposinho; João D. G. Correia; Maria Cristina Oliveira; Isabel Santos
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 2010
- Tongue
- English
- Weight
- 195 KB
- Volume
- 94
- Category
- Article
- ISSN
- 0006-3525
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## BACKGROUND. Previous studies have shown that the compact structure of a rhenium-cyclized ␣-melanocyte-stimulating hormone peptide analog, [Cys 3,4,10 ,D- Phe 7 ]␣-MSH 3-13 , or Re-CCMSH, significantly enhanced its in vivo tumor uptake and retention. In this study, the metal chelate 1,4,7,10-tet
## Abstract α‐Melanocyte stimulating hormone (αMSH), Ac‐Ser^1^‐Tyr^2^‐Ser^3^‐Met^4^‐Glu^5^‐His^6^‐Phe^7^‐Arg^8^‐Trp^9^‐Gly^10^‐Lys^11^‐Pro^12^‐Val^13^‐NH~2~, is an endogenous agonist for the melanocortin receptor 1 (MC1R), the receptor found in the skin, several types of immune cells, and other per