MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-XL, and Mcl-1 and promotes survival of human pancreatic cancer cells

bcl-2 over-expression delays radiation-i

bcl-2 over-expression delays radiation-induced apoptosis without affecting the clonogenic survival of human prostate cancer cells

✍ Natasha Kyprianou; Edward D. King; David Bradbury; Juong G. Rhee 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 394 KB 👁 1 views

In this study we evaluated the effect of over-expression of the bcl-2 gene, a potent apoptosis suppressor, on radiationinduced apoptotic cell death in 2 human prostate cancer cell lines, androgen-independent PC-3 cells and androgen-sensitive LNCaP cells. Cells were transfected with the bcl-2 gene an