Meiotic chromosome distribution inDrosophilaoocytes: Roles of two kinesin-related proteins
✍ Scribed by Sharyn A. Endow
- Publisher
- Springer
- Year
- 1992
- Tongue
- English
- Weight
- 867 KB
- Volume
- 102
- Category
- Article
- ISSN
- 0009-5915
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✦ Synopsis
Recent new information regarding the proteins required for proper distribution of chromosomes in meiosis has come from studies of Drosophila mutants. These studies reveal that proteins related to the microtubule motor protein, kinesin, function in meiotic chromosome segregation in Drosophila females. The two proteins identified thus far are likely to play very different roles in the process. The ncd protein is a spindle motor in meiosis but may perform a different role in the early mitotic divisions of the embryo, nod functions earlier in meiosis than ncd, prior to the meiotic divisions, and may be either chromosome or spindle associated. The identification of nod as a kinesin protein raises new questions regarding the distributive model of meiotic chromosome segregation.
Chromosome distribution
The process of chromosome distribution in dividing cells is not well understood, despite the large amount of effort that has gone into its study. Information both from cell biological and genetic approaches has provided an overall picture of the process; however, the cell and molecular biology of chromosome distribution are not well defined. We still do not know what causes chromosomes