## Abstract Inherited defects in DNA mismatch repair (MMR) predispose to a variety of malignancies in humans and in mouse knockout models. In humans, hemizygosity for one of several DNA MMR genes greatly increases an individual's risk for colon and endometrial carcinoma. Hemizygous mice develop gas
Meiotic arrest and aneuploidy in MLH3-deficient mice
β Scribed by Lipkin, Steven M.; Moens, Peter B.; Wang, Victoria; Lenzi, Michelle; Shanmugarajah, Dakshine; Gilgeous, Abigail; Thomas, James; Cheng, Jun; Touchman, Jeffrey W.; Green, Eric D.; Schwartzberg, Pam; Collins, Francis S.; Cohen, Paula E.
- Book ID
- 109919780
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 1000 KB
- Volume
- 31
- Category
- Article
- ISSN
- 1061-4036
- DOI
- 10.1038/ng931
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## Abstract Meiotic cell cycle in mammalian oocytes is a dynamic process that involves several stop/go channels. The cell cycle arrest in oocyte occurs at various stages such as diplotene, metaphaseβI (MβI), metaphaseβII (MβII), and so called metaphaseβlike arrest (MβIII). Leutinizing hormone surge