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Meige syndrome: Neuropathology of a case

✍ Scribed by J. Kulisevsky; M. J. Marti; I. Ferrer; Dr. E. Tolosa

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 508 KB
Volume: 3
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.870030209

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✦ Synopsis

Primary Meige syndrome is a form of cranial dystonia of unknown cause. Only three postmortem studies have been reported, and the results of these studies have not been consistent. We have examined the brain of a 72-year-old man with typical primary Meige syndrome and found mild to moderate cell loss in the zona compacta of the substantia nigra, locus ceruleus, midbrain tectum, and dentate nucleus of the cerebellum. Also frequent Lewy bodies were present in pigmented nuclei of the brainstem. No abnormalities were detected elsewhere. These pathological findings support the notion that brainstem pathology is important in the pathophysiology of cranial dystonia.

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