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Megalin Knockout Mice as an Animal Model of Low Molecular Weight Proteinuria

✍ Scribed by Jörg-Robert Leheste; Boris Rolinski; Henrik Vorum; Jan Hilpert; Anders Nykjaer; Christian Jacobsen; Pierre Aucouturier; Jan Øivind Moskaug; Albrecht Otto; Erik Ilsø Christensen; Thomas E. Willnow

Book ID
117022606
Publisher
American Society for Investigative Pathology
Year
1999
Tongue
English
Weight
881 KB
Volume
155
Category
Article
ISSN
0002-9440

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✍ Ulf G. Eriksson; Lars Renberg; Ulf Bredberg; Ann-Catrine Teger-Nilsson; Carl Gun 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 233 KB 👁 2 views

Pharmacokinetics, excretion, and metabolism of inogatran, a low-molecular-weight thrombin inhibitor, were studied in the rat, dog, and cynomolgus monkey. After intravenous administration the half-life was short in all three animal species, due to a small volume of distribution and a relatively high