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Megakaryocytic blast crisis as first presentation of chronic myeloid leukemia

✍ Scribed by L. Campiotti; A.M. Grandi; M.G. Biotti; C. Ultori; F. Solbiati; R. Codari; A. Venco

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
149 KB
Volume
82
Category
Article
ISSN
0361-8609

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✦ Synopsis

Abstract

We describe an extremely rare case of megakaryocytic blast crisis as first presentation of chronic myeloid leukemia. The patient had a very high platelet count and developed an ischemic stroke with seizures. She was treated with hydroxyurea, platelet apheresis, ARA‐C, and idarubicin in order to obtain a prompt reduction of thrombocytosis and then with imatinib 600 mg/die PO. The therapy induced a complete hematological remission with a resolution of neurological signs within 4 weeks. Am. J. Hematol., 2007. Β© 2006 Wiley‐Liss, Inc.

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