Megakaryocyte dysplasia in primary myelofibrosis
โ Scribed by Barbara J. Bain
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 94 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0361-8609
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๐ SIMILAR VOLUMES
Megakaryocytes (MKs) develop from diploid progenitor cells via successive rounds of DNA synthesis in the absence of cell division, a process termed endomitosis (EnM). While the mechanism underlying EnM is not known, studies in yeast and leukemic cell lines have suggested that it may be due to reduce
## Abstract ## BACKGROUND. Previous prognostic studies in primary myelofibrosis have focused on risk factors for overall survival and have resulted in the establishment of several prognostic scoring systems. However, to the authors' knowledge, information regarding risk factors for leukemic transf