✦ LIBER ✦
Medicinal Flowers. Part 29. Acylated Oleanane-Type Triterpene Bisdesmosides: Perennisaponins G, H, I, J, K, L, and M with Pancreatic Lipase Inhibitory Activity from the Flowers of Bellis perennis
✍ Scribed by Toshio Morikawa; Xuezheng Li; Eriko Nishida; Seikou Nakamura; Kiyofumi Ninomiya; Hisashi Matsuda; Yoshimi Oda; Osamu Muraoka; Masayuki Yoshikawa
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- German
- Weight
- 228 KB
- Volume
- 93
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
Abstract
The MeOH extract from the flowers of Bellis perennis was found to show pancreatic‐lipase inhibitory activity (IC~50~ 455 μg/ml). From the extract, seven new triterpene saponins named perennisaponins G (1; IC~50~ 163 μM), H (2; 137 μM), I (3; 147 μM), J (4; 148 μM), K (5; 223 μM), L (6; 81.4 μM), and M (7; 195 μM) were isolated as pancreatic lipase inhibitors. The stereostructures of 1–7 were elucidated on the basis of chemical and spectroscopic evidence.