𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Medical radiation exposure and breast cancer risk: Findings from the Breast Cancer Family Registry

✍ Scribed by Esther M. John; Amanda I. Phipps; Julia A. Knight; Roger L. Milne; Gillian S. Dite; John L. Hopper; Irene L. Andrulis; Melissa Southey; Graham G. Giles; Dee W. West; Alice S. Whittemore

Publisher
John Wiley and Sons
Year
2007
Tongue
French
Weight
111 KB
Volume
121
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Moderate to high‐dose radiotherapy is known to increase the risk of breast cancer. Uncertainties remain about the effects of low‐dose chest X‐rays, particularly in individuals at increased genetic risk. We analyzed case‐control data from the Breast Cancer Family Registry. Self‐reported data on therapeutic and diagnostic radiation exposures to the chest were available for 2,254 breast cancer cases and 3,431 controls (1,556 unaffected sisters and 1,875 unrelated population controls). We used unconditional logistic regression analyses to estimate odds ratios (OR) and 95% confidence intervals (CI) associated with radiation exposure, after adjusting for age, study center, country of birth, and education. Increased risks for breast cancer were found for women who had radiotherapy for a previous cancer (OR = 3.55, CI = 1.47–8.54) and diagnostic chest X‐rays for tuberculosis (OR = 2.49, CI = 1.82–3.40) or pneumonia (OR = 2.19, CI = 1.38–3.47). Risks were highest for women with a large number of exposures at a young age or exposed in earlier calendar years. There was no evidence of increased risk associated with other diagnostic chest X‐rays (not including tuberculosis or pneumonia), both in women with and without indicators of increased genetic risk (i.e., diagnosed at age <40 years or family history of breast cancer). Given the widespread and increasing use of medical diagnostic radiation, continued surveillance of breast cancer risk is warranted, particularly in women at specific genetic risk, such as those carrying mutations in BRCA1 or BRCA2. © 2007 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

An inverse association between ovarian c
An inverse association between ovarian cysts and breast cancer in the breast cancer family registry
✍ Julia A. Knight; Esther M. John; Roger L. Milne; Gillian S. Dite; Ron Balbuena; 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 87 KB 👁 1 views

## Abstract Ovarian cysts of several types are common in women of reproductive age. Their etiology is not well understood but is likely related to perturbations in the hypothalamic‐pituitary‐gonadal axis. The relationship of ovarian cysts to breast cancer risk is not known, although a negative asso

Familial clustering of breast cancer: Po
Familial clustering of breast cancer: Possible interaction between dna repair proficiency and radiation exposure in the development of breast cancer
✍ Kathy J. Helzlsouer; Emily L. Harris; R. Parshad; Sandy Fogel; William L. Bigbee 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 430 KB 👁 2 views

## Abstract The capacity of peripheral blood lymphocytes to repair X‐ray‐induced DNA damage, manifest as chromatid damage 30‐90 min after G~2~‐phase X‐irradiation, was measured among available members of a family exhibiting a cluster of breast‐cancer cases occurring in one generation. The cancer pa

Abortion history and breast cancer risk:
Abortion history and breast cancer risk: Results from the Shanghai breast cancer study
✍ Maureen Sanderson; Xiao-Ou Shu; Fan Jin; Qi Dai; Wanqing Wen; Yi Hua; Yu-Tang Ga 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 61 KB 👁 1 views

Studies of the association between induced abortion and breast cancer risk have been inconsistent, perhaps due to underreporting of abortions. Induced abortion is a well-accepted family planning procedure in China, and women who have several induced abortions do not feel stigmatized. The authors use

Mammographic findings and family history
Mammographic findings and family history risk for breast cancer in American Indian women
✍ Marilyn A. Roubidoux; Judith Salmon Kaur; Jennifer Giroux 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 86 KB 👁 2 views

Access to annual screening mammography among American Indians is limited, and data regarding breast cancer risk factors or mammography in these women are scarce. Although average breast cancer mortality rates are lower than those of all races in the United States, rates vary widely between tribes (3

Body size and breast cancer risk: Findin
Body size and breast cancer risk: Findings from the European prospective investigation into cancer and nutrition (EPIC)
✍ Petra H. Lahmann; Kurt Hoffmann; Naomi Allen; Carla H. van Gils; Kay-Tee Khaw; B 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 169 KB 👁 2 views

## Abstract The evidence for anthropometric factors influencing breast cancer risk is accumulating, but uncertainties remain concerning the role of fat distribution and potential effect modifiers. We used data from 73,542 premenopausal and 103,344 postmenopausal women from 9 European countries, tak