Mediators of oligodendrocyte differentiation during remyelination
β Scribed by Jigisha R. Patel; Robyn S. Klein
- Book ID
- 113622537
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 430 KB
- Volume
- 585
- Category
- Article
- ISSN
- 0014-5793
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π SIMILAR VOLUMES
## Abstract While numerous oligodendrocyte progenitor cells (OPCs) exist in the adult central nervous system (CNS), the molecular signals that promote or inhibit their differentiation into mature oligodendrocytes (OLs) are not known. To investigate whether remyelination in the adult CNS is regulate
Endogenous oligodendrocyte lineage cells spontaneously remyelinate focal areas of demyelination induced by murine hepatitis virus A59 infection of C57Bl/6 mice. We used this model to examine the potential for platelet-derived growth factor (PDGF) to have a role in repopulating demyelinated lesions,