✦ LIBER ✦

Mediation by serotonin of gold thioglucose-induced necrosis of the ventromedial hypothalamus

✍ Scribed by A. F. Debons; I. Krimsky; Annette From; E. Siclari

Publisher: John Wiley and Sons
Year: 1979
Tongue: English
Weight: 860 KB
Volume: 129
Category: Article
ISSN: 0022-3417
DOI: 10.1002/path.1711290206

No coin nor oath required. For personal study only.

✦ Synopsis

Agents that lower serotonin levels or inhibit serotonin action prevent GTG-indurea and that such damage leads to abnormally increased capillary permeability. Since the VMH is rich in serotonin and since serotonin is a potent oedema-producing agent mice, these findings indicate that the production of necrosis by GTG is mediated by release of serotonin from the damaged pericapillary processes.

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