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MeCP2 and other methyl-cpg binding proteins

✍ Scribed by Jørgensen, Helle Faerk ;Bird, Adrian

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
293 KB
Volume
8
Category
Article
ISSN
1080-4013

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✦ Synopsis

DNA methylation is an epigenetic modification that is implicated in transcriptional silencing. Recently, it has become increasingly clear that both correct levels and proper interpretation of methylation are important factors for normal development and function of the human organism. One example is the neurological disorder Rett syndrome (RTT), which affects approximately one in 10,000 girls. RTT is caused by mutations in MeCP2, a protein that was identified by its ability to bind specifically to CpG-methylated DNA. Furthermore, MeCP2 represses transcription in a methylation-dependent manner, and it is the founding member of the family of methyl-CpG binding domain (MBD) proteins.

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