𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Mechatronic design methodology for biotechnology products

✍ Scribed by C.F. Mandenius; M. Björkman

Publisher
Elsevier
Year
2009
Tongue
English
Weight
79 KB
Volume
25
Category
Article
ISSN
1871-6784

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✦ Synopsis

concentrated substrate solutions to each well of the microtiter plate individually are possible. Fermentations with pH control as well as fed-batch fermentations with different feeding strategies (constant, linear increasing, exponential) have been performed with Escherichia coli. The results obtained with the microfluidic controlled microtiter plates can be reproduced in parallel fermentations in 1L laboratory-scale stirred tank reactor.

Besides the microfluidic control, the fermentations are monitored online with the BioLector-technology. This fiber-optic measurement system, developed in our group, allows an online monitoring of biomass (via scattered light detection), metabolism (e.g. via NADH fluorescence) and production (via GFP, YFP fluorescence). The combination of the microfluidics in microtiter plates and the BioLector online-monitoring technology allows high-throughput as well as data acquisition and process control in small-scale comparable to industrial production processes.

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