Mechanosensitive Ion Channels

✍ Scribed by Andre Kamkin, Irina Kiseleva, Ilya Lozinsky (auth.), Andre Kamkin, Irina Kiseleva (eds.)

• Publisher: Springer Netherlands
• Year: 2008
• Tongue: English
• Leaves: 389
• Series: Mechanosensitivity in Cells and Tissues 1
• Edition: 1
• Category: Library

✦ Synopsis

This book is devoted to discussing the latest data dealing with mechanosensitive channels research results.

It was compiled by a group of internationally recognized scientists leading in the field of mechanosensitive ion channels or mechanically gated channels and mechanosensitive signaling cascades research.

Key problems of cell mechanobiology are also discussed.

The reviews included here deal with experimental methods of studying mechanosensitive channels, role of lipid bilayer mechanics in mechanosensation, molecular organization, physiology and pharmacology of various channels reacting to membrane tension as a stimulus.

The book also examines mechanotransduction, which the authors define as the biochemical response of cells to mechanical stimulation.

As a whole, the volume dwells on the major issues of mechanical stress influencing the ion channels and intracellular signaling pathways.

The book presents not only the latest achievements in the field but also brings the understanding of the problem closer to the experts in related medical and biological sciences as well as practicing doctors.

✦ Table of Contents

Front Matter....Pages I-XXI
Front Matter....Pages 1-1
Experimental Methods of Studying Mechanosensitive Channels and Possible Errors in Data Interpretation....Pages 3-35
Role of Lipid Bilayer Mechanics in Mechanosensation....Pages 37-70
Mechanosensitive Channels Gated by Membrane Tension....Pages 71-101
Computational Studies of the Bacterial Mechanosensitive Channels....Pages 103-116
Mechanosensory Transduction in the Nematode Caenorhabditis elegans ....Pages 117-145
Mechanosensitive Ion Channels in Odontoblasts....Pages 147-155
Potassium Ion Channels in Articular Chondrocytes....Pages 157-178
Osmotransduction Through Volume-Sensitive Cl - Channels....Pages 179-202
Mechanosensitive Channel TRPV4....Pages 203-231
Front Matter....Pages 233-233
Mechanosensitive Purinergic Calcium Signalling in Articular Chondrocytes....Pages 235-251
Signal Transduction Pathways Involved in Mechanotransduction in Osteoblastic and Mesenchymal Stem Cells....Pages 253-265
Caveolae....Pages 267-289
Multimodal Activation and Regulation of Neuronal Mechanosensitive Cation Channels....Pages 291-302
Regulation of Intracellular Signal Transduction Pathways by Mechanosensitive Ion Channels....Pages 303-327
Front Matter....Pages 329-329
The Effects of Mechanical Stimulation on Vertebrate Hearts....Pages 331-350
Mechanobiology of Fibroblasts....Pages 351-378
Back Matter....Pages 379-381

✦ Subjects

Cell Biology;Animal Physiology;Biophysics/Biomedical Physics;Physiological, Cellular and Medical Topics