Mechanistic studies on type I and type II dehydroquinase with (6R)- and (6S)-6-fluoro-3-dehydroquinic acids

✍ Scribed by Emily J Parker; Concepción González Bello; John R Coggins; Alastair R Hawkins; Chris Abell

• Publisher: Elsevier Science
• Year: 2000
• Tongue: English
• Weight: 163 KB
• Volume: 10
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/s0960-894x(99)00660-5

✦ Synopsis

(6R)- and (6S)-6-Fluoro-3-dehydroquinic acids are shown to be substrates for type I and type II dehydroquinases. Their differential reactivity provides insight into details of the reaction mechanism and enables a novel enzyme-substrate imine to be trapped on the type I enzyme.