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Mechanistic studies on the double activation method for the synthesis of macrocyclic lactones

โœ Scribed by E.J. Corey; Daniel J. Brunelle; Philip J. Stork


Publisher
Elsevier Science
Year
1976
Tongue
French
Weight
215 KB
Volume
17
Category
Article
ISSN
0040-4039

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Studies on the total synthesis of rifamy
โœ E.J. Corey; David A. Clark ๐Ÿ“‚ Article ๐Ÿ“… 1980 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 204 KB

The formation of the macro ring of rifamycin S (4) has been accomplished by generating the lactam linkage through cyclization of a suitably protected and activated amino acid (4). 1 Previous papers from these laboratories on the synthesis of rifamycin S (1) have dealt with 2 in 80% yield occurs unde