Studies on the total synthesis of rifamy
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E.J. Corey; David A. Clark
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Article
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1980
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Elsevier Science
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French
โ 204 KB
The formation of the macro ring of rifamycin S (4) has been accomplished by generating the lactam linkage through cyclization of a suitably protected and activated amino acid (4). 1 Previous papers from these laboratories on the synthesis of rifamycin S (1) have dealt with 2 in 80% yield occurs unde