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Mechanistic Studies of an Unusual Amide Bond Scission

✍ Scribed by Creighton, Christopher J.; Romoff, Todd T.; Bu, Jane H.; Goodman, Murray


Book ID
120208554
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
173 KB
Volume
121
Category
Article
ISSN
0002-7863

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Mechanistic studies of amide bond scissi
✍ Chiara Rubini; Alessio Osler; Andrea Calderan; Andrea Guiotto; Paolo Ruzza πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 257 KB

## Abstract Unusual TFA catalyzed cleavage reaction is reported for peptide containing pipecolic acid residues. Although the use of TFA under standard cleavage conditions is sufficiently mild to prevent degradation of the desired products, the amide bond between consecutive pipecolic acid residues