Mechanistic studies of amide bond scissi
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Chiara Rubini; Alessio Osler; Andrea Calderan; Andrea Guiotto; Paolo Ruzza
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Article
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2008
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John Wiley and Sons
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English
β 257 KB
## Abstract Unusual TFA catalyzed cleavage reaction is reported for peptide containing pipecolic acid residues. Although the use of TFA under standard cleavage conditions is sufficiently mild to prevent degradation of the desired products, the amide bond between consecutive pipecolic acid residues