Catalyzed acyl halideξΈaldehyde cyclocond
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Scott G. Nelson; Zhonghui Wan; Timothy J. Peelen; Keith L. Spencer
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Article
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1999
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Elsevier Science
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French
β 295 KB
Substoichiometric quantities (2.5-20 tool%) of AI(SbF6)3 catalyze the di(isopropyl)ethylamine-mediated cyclocondensation of various acyl halides and enolizable aldehydes to afford I$-lactones in good yields (58-93%). These reactions are discussed as a strategy for executing chemo-and regiospecific c