𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Mechanistic approach of the nucleophilic18F- exchange on 4′-NO2-spiperone using TBA18F or K2.2.2./K18F

✍ Scribed by M. Gysemans; J. Mertens

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
356 KB
Volume
28
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

High yield single step preparation of 4′‐^18^F‐spiperone by ^18^F‐ for NO~2~ exchange in highly basic conditions fails when using 4′‐NO~2~‐spiperone as a precursor. This compound moreover inhibits radiofluorination of highly activated molecules in mentioned conditions. Inhibition is not provoced by ketalised analogues of the butyrophenone. This led to assume that enolisation of the butyrophenone was responsible for those phenomena. The assumption is supported by the fact that the results of inhibition experiments fit to a theoretical model.

📜 SIMILAR VOLUMES

2-, 3- and 4-[18F]Fluoropyridine by no-c
2-, 3- and 4-[18F]Fluoropyridine by no-carrier-added nucleophilic aromatic substitution with K[18F]F-K222 – a comparative study
✍ M. Karramkam; F. Hinnen; F. Vaufrey; F. Dollé 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 152 KB

## Abstract Compared to homoaromatic and aliphatic nucleophilic radiofluorinations, only few references can be found in the literature describing nucleophilic substitutions with [^18^F]fluoride ion of heteroaromatic compounds such as pyridines and only reactions involving fluorination processes at

Mechanistic approach of the difference i
Mechanistic approach of the difference in hydrolysis rate between the 2- and 4-isomers of no-carrier-added [18F]fluoromethyl-L-phenylalanine
✍ Ken Kersemans; John Mertens; Frank De Proft; Paul Geerlings 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 159 KB

## Abstract No‐carrier‐added (n.c.a.) 2‐[^18^F]fluoromethyl‐l‐phenylalanine (2‐[^18^F]FMP) was found to be very sensitive to hydrolysis in aqueous solutions. In this paper, the defluorination reaction was studied in detail to elucidate its mechanism. Therefore, besides 2‐[^18^F]FMP and 4‐[^18^F]FMP

Mechanistic approach of the difference i
Mechanistic approach of the difference in non-enzymatic hydrolysis rate between the L and D enantiomers of no-carrier added 2-[18F]fluoromethyl-phenylalanine
✍ Ken Kersemans; John Mertens; Frank De Proft; Paul Geerlings 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 227 KB

## Abstract No‐carrier added (n.c.a.) 2‐[^18^F]fluoromethyl‐l‐phenylalanine was found to be very sensitive to hydrolysis in aqueous solutions. This problem was solved partially by the addition of calcium ions (0.04 M), increasing the shelf‐life to at least 6 h. In this paper the defluorination reac

No-carrier-added (NCA) synthesis of 6-[1
No-carrier-added (NCA) synthesis of 6-[18F]fluoro-L-DOPA using 3,5,6,7,8,8a-hexahydro-7,7,8a-trimethyl-[6s-(6α,8α,8αβ)]-6,8-methano-2H-1,4-benzoxazin-2-one
✍ Andrew Horti; D. Eugene Redmond Jr.; Robert Soufer 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 583 KB

## No-carrier-added (NCA) synthesis of 6-[18F]fluoro-L-DOPA using 3, 5, 6, 7, 8, 7, 8a t r i m e t h y l -[ 6s -( 6 a , 8a, 8a p ) ] -6 , 8 -m e t h a n 0 -2 H -1,4b e n z o x a z i n -2 -o n e .