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Mechanistic and pharmacokinetic considerations in the use of topotecan alone and in combination

✍ Scribed by Johnson, Randall K.

Book ID
118575270
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
81 KB
Volume
18
Category
Article
ISSN
0169-5002

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Multiple oral doses of diltiazem (DTZ) and propranolol (PPL, 60 mg every 8 h daily for 13 doses) were administered to 14 healthy volunteers alone and in combination on three separate occasions. Serial blood samples were collected up to 24 h after dose 13 on day 5 to determine possible pharmacokineti