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Mechanistic alternatives in Lewis acid-catalyzed acyl halidealdehyde cyclocondensations

✍ Scribed by Scott G. Nelson; Timothy J. Peelen; Zhonghui Wan


Book ID
104262092
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
182 KB
Volume
40
Category
Article
ISSN
0040-4039

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Catalyzed acyl halidealdehyde cyclocond
✍ Scott G. Nelson; Zhonghui Wan; Timothy J. Peelen; Keith L. Spencer 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 295 KB

Substoichiometric quantities (2.5-20 tool%) of AI(SbF6)3 catalyze the di(isopropyl)ethylamine-mediated cyclocondensation of various acyl halides and enolizable aldehydes to afford I$-lactones in good yields (58-93%). These reactions are discussed as a strategy for executing chemo-and regiospecific c

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